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1.?Ping Liu, Sulin Zhang, Bingyi Chen, Bin-He Chang, Yi-Lun Jiang, Xi-Ya Li, Xinchi? Chen, Zi-Juan Li, Ruirui Yang, Xiaoning Wang, Chun-Hui Xu, Xiaomeng Liu, Na Liu, Yuanyuan Jia, Pengcheng Yu, Yong Wang, Li-Juan Zong, Cheng-Long Hu, Hui Hou, Duanhua Cao, Xutong Li, Chuhan Deng, Yi-Yi Ren, Muying Zhao, Xinyi Ma, Rongrong Cui, Dan Teng, Miao Chen, Roujia Wang, Jiacheng Jin, Shiyu Jiang, Xiao-Jing Yan, Kai Xue, Qunling Zhang, Jianfeng Li, Enyong Dai, Shuhong Shen, Zhikai Wang, Xueshi Ye, Jin Zhang, Yu Liu, Wengguo Cui, Min Lu, Wei-Li Zhao, Chun-Kang Chang, Pengcheng He, Zhu Chen, Sai-Juan Chen, Mingyue Zheng, Xiao-Jian Sun*, Lan Wang*. Targeting RBPMS selectively eliminates FOXO1-mediated stem cell signatures in acute myeloid leukemia. Science Translational Medicine.2026; 18(848): eadv8951.

2.?Zi-Juan Li, Muying Zhao, Roujia Wang, Na Liu, Cheng-Long Hu, Bin-He Chang, Fang Hu, Xi-Ya Li, Chun-Hui Xu, Ping Liu, Bingyi Chen, Shu-Bei Chen, Yong Wang, Qi-Jing Li, Busheng Xue, Chuhan Deng, Xinchi Chen, Yiyi Ren, Jia-Cheng Jin, Xiao Yan, Yuanliang Zhang, Robert Gale, Jianfei Fu, Qunling Zhang, Xiaoning Wang, Qiu-Hua Huang, Yan Liu, Ju Qiu, Jun Qin, Xueshi Ye, Jin Zhang, Yang Liang, Zhu Chen, Sai-Juan Chen, Peng-Cheng He*, Chun-Kang Chang*, Xiao-Jian Sun*, Lan Wang*. Site specific methylation of SRSF2P95H by SETD2 inhibits MDSCs-mediated proinflammatory niche formation in myelodysplastic syndrome. Science Translational Medicine. 2026; 18(843): eadv1065.

3.?Ailing Gui, Yichen Yan, Shiyu Jiang, Feng Chen, Xiaolong Zhou, Qi Sun, Shi Qiu, Jichuan Wu, Xiya Li, Junyi Zhang, Jie Liu, Shun Zhu, Lan Wang, Wen Liu, Ji Zuo*, Qunling Zhang*, Ling Yang*. USP1–TRAF2 axis–regulated mortalin stability mediates chemoresistance by disrupting calcium transport in peripheral T-cell lymphoma.?Proc Natl Acad Sci U S A.?2025; 122(48): e2504195122.

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4. Kefei Wu,?Hui Liu,?Wenting Hu,?Yuhan Liu^?,?Wenyan Wu^?,?Bowen Cui,?Han Wang^?,?Shuang?Zhao^?,?Yanjing Tang,?Jiaoyang Cai^?,?Yong Wang^?,?Xiang Wang,?Xiaoxiao Chen,?Yixiao Mo^?,?Ting Liu,?Yangyang Xie,?Huiying Sun,?Ying Zhong,?Jianan Rao^?,?Rongrong Fan^?,?Ying Wang,?Changcheng Chen,?Zhuo Wang,?Ronghua Wang,?Yuanlu Huang,?Qiaoqiao Shi,?Lan Wang^?,?Jing Chen^?,?Jing Chen,?Benshang Li,?Xiaolong Chen*,?Yu Liu*,?Shuhong Shen*. Clinically associated genomic landscape of pediatric non-Down Syndrome acute megakaryoblastic leukemia in Chinese patients. Leukemia. 2025; 39(10):2533-2537.

5. Miao Chen, Wen-Ze Li, Yuan Tao, Cheng-Long Hu, Rui Ge, Si-Jing Kang, Peng-Jie Yue, Cheuk Him Man, Lan Wang*, Xiaojing Yan*.?SLC25A1 reprograms mitochondrial and fatty acid metabolism to promote the progression of acute myeloid leukemia. Haematologica. 2025.?doi: 10.3324/haematol.2024.287269.

6. Shu-Bei Chen, Dian-Jia Liu, Bing-Yi Chen, Zi-Juan Li, Bin-He Chang, Chun-Hui Xu, Ning-Zhe Li, Chang-Zhou Feng, Xi-Bo Hu, Wei-Ying Wang, Yuan-Liang Zhang, Yin-Yin Xie, Qiu-Hua Huang, Ying-Cai Wang, Stephen D Nimer, Sai-Juan Chen, Zhu Chen, Lan Wang*, Xiao-Jian Sun*. Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation. Front Med.?2024;?18(5):?831-849.

7. Ning-Zhe Li, Zi-Xuan Wang, Fan Zhang, Chang-Zhou Feng, Yi Chen, Dian-Jia Liu, Shu-Bei Chen, Yi Jin, Yuan-Liang Zhang, Yin-Yin Xie, Qiu-Hua Huang, Lan Wang, Bing Li, Xiao-Jian Sun. Threonine dehydrogenase regulates neutrophil homeostasis but not H3K4me3 levels in zebrafish. The FEBS Journal. 2024; 291(15):3367-3383.

8. Feng Chen, Shi Qiu, Ai-Ling Gui, Shi-Yu Jiang, Yi-Chen Yan, Ji-Chuan Wu, Guang-Liang Chen, Shun Zhu, Yi-Zhen Liu, Zu-Guang Xia, Bao-Hua Yu, Xiao-Jian Sun, Juan Jennifer Gu,?Lan Wang, Wen Liu, Ling Yang, Qun-ling Zhang, Ji Zuo. Reduced OTUD7B expression correlates with poor prognosis in PTCL via non-canonical NF-κB. International Journal of Hematology. 2024; 121(2):194-205.

9. Peng-Cheng Yu, Dan Hou, Binhe Chang, Na Liu, Chun-Hui Xu, Xinchi Chen, Cheng-Long Hu, Ting Liu, Xiaoning Wang, Qunling Zhang, Ping Liu, Yilun Jiang, Ming-Yue Fei, Li-Juan Zong, Jia-Ying Zhang, Hui Liu, Bing-Yi Chen, Shu-Bei Chen, Yong Wang, Zijuan Li, Xiya Li, Chu-Han Deng, Yi-Yi Ren, Muying Zhao,Shiyu Jiang, Roujia Wang, Jiacheng Jin, Shaoxin Yang, Kai Xue, Jun Shi, ChunKang Chang, Shuhong Shen, Peng-Cheng He, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun,?Lan Wang*. SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis.?Developmental Cell?2024 Aug 5;59(15):1954-1971.

10. Wu X, Wang Y, Chen B, Liu Y, Li F, Ou Y, Zhang H, Wu X, Li X, Wang L, Rong W, Liu J, Xing M, Zhao X, Liu H, Ge L, Lv A,?Wang L, Wang Z, Li M, Zhang H. ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression.?Advanced Science?2024 Jan;11(3):e2303555.

11. Jia-Cheng Jin, Bing-Yi Chen, Chu-Han Deng, Jia-Nan Chen, Feng Xu, Ying Tao, Cheng-Long Hu, Chun-Hui Xu, Bin-He Chang, Yong Wang, Ming-Yue Fei, Ping Liu, Peng-Cheng Yu, Zi-Juan Li, Xi-Ya Li, Shu-Bei Chen, Yi-Lun Jiang, Xin-Chi Chen, Li-Juan Zong, Jia-Ying Zhang, Yi-Yi Ren, Fan-Huan Xu, Qi Liu, Xin-Hui Huang, Juan Guo, Qi He, Lu-Xi Song, Li-Yu Zhou, Ji-Ying Su, Chao Xiao, Yu-Mei Zhang, Meng Yan, Zheng Zhang, Dong Wu, Chun-Kang Chang, Xiao Li,?Lan Wang*, Ling-Yun Wu*. ROBO1 deficiency impairs HSPCs homeostasis and erythropoiesis via CDC42 and predicts poor prognosis in MDS.?Science Advances?2023 Dec;9(48):eadi7375.

12. Xie J, Sheng M, Rong S, Zhou D, Wang C, Wu W, Huang J, Sun Y, Wang Y, Chen P, Wu Y, Wang Y,?Wang L, Zhou BO, Huang X, Walsh CP, Bohlander SK, Huang J, Wang X, Xu GL, Gao H, Shi Y. STING activation in TET2-mutated hematopoietic stem/progenitor cells contributes to the increased self-renewal and neoplastic transformation.?Leukemia?2023 Dec;37(12):2457-2467.

13. Fei MY, Wang Y, Chang BH, Xue K, Dong F, Huang D, Li XY, Li ZJ, Hu CL, Liu P, Wu JC, Yu PC, Hong MH, Chen SB, Xu CH, Chen BY, Jiang YL, Liu N, Zhao C, Jin JC, Hou D, Chen XC, Ren YY, Deng CH, Zhang JY, Zong LJ, Wang RJ, Gao FF, Liu H, Zhang QL, Wu LY, Yan J, Shen S, Chang CK, Sun XJ,?Wang L*. The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.?Blood?2023 Sep 7;142(10):903-917.

14. Dan Liu, Chun-Hui Xu, Yan-Ting Liu, Wen Ouyang, Shao-Jian Lin, Ai-Ning Xu, Yuan-Liang Zhang, Yin-Yin Xie, Qiu-Hua Huang, Wei-Li Zhao, Zhu Chen,?Lan Wang, Sai-Juan Chen*, Jin-Yan Huang*, Zhe-Bao Wu*, Xiao-Jian Sun*. A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumor.?Frontiers of medicine?2023 Jun;17(3):458-475.

15. Roujia Wang, Youshan Zhao, Zijuan Li,Juan Guo, Sida Zhao, Luxi Song, Dong Wu,?Lan Wang*, Chunkang Chang*. S100a9 deficiency accelerates MDS associated tumor escape via PD-1/PD-L1 overexpression.?Acta Biochimica etBiophysica Sinica?2023 Feb 25;55(2):194-201.

16. Xi-Ya Li, Ji-Chuan Wu, Ping Liu, Zi-Juan Li, Yong Wang, Bing-Yi Chen, Cheng-Long Hu, Ming-Yue Fei, Peng-Cheng Yu, Yi-Lun Jiang, Chun-Hui Xu, Bin-He Chang, Xin-Chi Chen, Li-Juan Zong, Jia-Ying Zhang, Ying Fang, Xiao-Jian Sun, Kai Xue, Li Wang, Shu-Bei Chen, Shi-Yu Jiang, Ai-ling Gui, Ling Yang, Juan J. Gu, Bao-Hua Yu, Qun-ling Zhang*,?Lan Wang*. Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B cell lymphoma.?Leukemia?2023 Jan; 37(1):164-177.

17. Cheng-Long Hu, Bing-Yi Chen, Zijuan Li, Tianbiao Yang, Chun-Hui Xu, Ruirui Yang, Peng-Cheng Yu, Jingyao Zhao, Ting Liu, Na Liu, Bin Shan, Qunling Zhang, Junhong Song, Ming-Yue Fei, Li-Juan Zong, Jia-Ying Zhang, Ji-Chuan Wu, Shu-Bei Chen, Yong Wang, Binhe Chang, Dan Hou, Ping Liu, Yilun Jiang, Xiya Li, Xinchi Chen, Chu-Han Deng, Yi-Yi Ren, Roujia Wang, Jiacheng Jin, Kai Xue, Ying Zhang, Meirong Du, Jun Shi, Ling-Yun Wu, Chun-Kang Chang, Shuhong Shen, Zhu Chen, Sai-Juan Chen, Xiaolong Liu*, Xiao-Jian Sun*, Mingyue Zheng*,?Lan Wang*. Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia.?Cell Research?2022 Dec;32(12):1105-1123.

18. Meijuan Bai, Peijuan Cao, Yijun Lin, Pengcheng Yu, Shuo Song, Lingling Chen,?Lan Wang, Yan Chen*. Intermittent Caloric Restriction Promotes Erythroid Development and Ameliorates Phenylhydrazine-Induced Anemia in Mice.?Front Nutr?2022;9:892435.

19. Jinxi Li, James D Glover, Haiguo Zhang, Meifang Peng, Jingze Tan, Chandana Basu Mallick, Dan Hou, Yajun Yang, Sijie Wu, Yu Liu, Qianqian Peng, Shijie C Zheng, Edie I Crosse, Alexander Medvinsky, Richard A Anderson, Helen Brown, Ziyu Yuan, Shen Zhou, Yanqing Xu, John P Kemp, Yvonne Y W Ho, Danuta Z Loesch, Lizhong Wang, Yingxiang Li, Senwei Tang, Xiaoli Wu, Robin G Walters, Kuang Lin, Ruogu Meng, Jun Lv, Jonathan M Chernus, Katherine Neiswanger, Eleanor Feingold, David M Evans, Sarah E Medland, Nicholas G Martin, Seth M Weinberg, Mary L Marazita, Gang Chen, Zhengming Chen, Yong Zhou, Michael Cheeseman,?Lan Wang, Li Jin, Denis J Headon, Sijia Wang*. Limb development genes underlie variation in human fingerprint patterns.?Cell?2022 Jan 6;185(1):95-112.

20. Yi-Fan Zhang, Xiao-Lin Wang, Chun-Hui Xu, Na Liu, Ling Zhang, Yu-Ming Zhang, Yin-Yin Xie, Yuan-Liang Zhang, Qiu-Hua Huang,?Lan Wang, Zhu Chen, Sai-Juan Chen, Robert G Roeder, Shuhong Shen, Kai Xue, Xiao-Jian Sun*. A direct comparison between AML1-ETO and ETO2-GLIS2 leukemia fusion proteins reveals context-dependent binding and regulation of target genes and opposite functions in cell differentiation.?Front Cell Dev Biol?2022 Sep 7;10:992714.

21. Fan Zhang, Qi-Yu Zeng, Hao Xu, Ai-Ning Xu, Dian-Jia Liu, Ning-Zhe Li, Yi Chen, Yi Jin, Chun-Hui Xu, Chang-Zhou Feng, Yuan-Liang Zhang, Dan Liu, Na Liu, Yin-Yin Xie, Shan-He Yu, Hao Yuan, Kai Xue, Jing-Yi Shi, Ting-Xi Liu, Peng-Fei Xu, Wei-Li Zhao, Yi Zhou,?Lan Wang, Qiu-Hua Huang, Zhu Chen, Sai-Juan Chen*, Xiao-Long Zhou*, Xiao-Jian Sun*. Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis.?Cell Discovery?2021;7(1):98.

22. Kai Xue, Ji-Chuan Wu, Xi-Ya Li, Ran Li, Qun-ling Zhang, Jin-Jia Chang, Yi-Zhen Liu, Chun-Hui Xu, Jia-Ying Zhang, Xiao-Jian Sun, Juan J. Gu, Wei-Jian Guo*,?Lan Wang*. Chidamide triggers BTG1-mediated autophagy and reverses the chemotherapy resistance in the relapsed/refractory B cell lymphoma.?Cell Death & Disease?2021;12(10):900.

23. Dian-Jia Liu, Fan Zhang, Yi Chen, Yi Jin, Yuan-Liang Zhang, Shu-Bei Chen, Yin-Yin Xie, Qiu-Hua Huang, Wei-Li Zhao,?Lan Wang, Peng-Fei Xu, Zhu Chen, Sai-Juan Chen, Bing Li, Ai-Jun Zhang, Xiao-Jian Sun*. Setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals.?Cell Discovery?2020;6:72.

24. Bing-Yi Chen, Jun-Hong Song, Cheng-Long Hu, Shu-Bei Chen, Qunling Zhang, Chun-Hui Xu, Ji-Chuan Wu, Dan Hou, Ming Sun, Yuan-Liang Zhang, Na Liu, Peng-Cheng Yu, Ping Liu, Li-Juan Zong, Jia-Ying Zhang, Ruo-fei Dai, Fei Lan, Qiu-Hua Huang, Su-Jiang Zhang, Stephen D Nimer, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun*,?Lan Wang*. SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS.?Blood?2020;35(25):2271-2285.

25. Na Liu, Jun-Hong Song, Yang-Yang Xie, Xiao-Lin Wang, Bo-Wen Rong， Na Man，Meng-Meng Zhang, Qun-Ling Zhang, Fei-Fei Gao, Mei-Rong Du, Ying Zhang, Jian Shen, Xu Chun Hui, Cheng-Long Hu, Ji-Chuan Wu, Ping Liu, Yuan-Liang Zhang, Yin-Yin Xie, Ping Liu, Jin-Yan Huang, Qiu-Hua Huang, Fei Lan, Shu-Hong Shen, Stephen D. Nimer, Zhu Chen, Sai-Juan Chen, Robert G. Roeder*,?Lan Wang*, Xiao-Jian Sun*. Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis.?Proc Natl Acad Sci U S A?2019;116(3):890-899.

26. Meng-Meng Zhang, Na Liu, Yuan-Liang Zhang, Bo-Wen Rong, Xiao-Lin Wang, Chun-Hui Xu, Yin-Yin Xie, Shu-Hong Shen, Jiang Zhu, Stephen D. Nimer, Zhu Chen, Sai-Juan Chen, Robert G Roeder, Fei Lan,?Lan Wang*, Qiu-Hua Huang*, Xiao-Jian Sun*. Destabilization of AETFC through C/EBPα-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation.?Leukemia?2019;33:1822-1827.

27. Ye Xu, Na Man, Daniel Karl, Concepcion Martinez, Fan Liu, Jun Sun, Camilo Jose Martinez, Gloria Mas Martin, Felipe Beckedorff, Fan Lai, Jing-Yin Yue, Alejandro Roisman, Sarah Greenblatt, Stephanie Duffort,?Lan Wang, Xiao-Jian Sun, Maria Figueroa, Ramin Shiekhattar*, Stephen D. Nimer*. TAF1 plays a critical role in AML1-ETO driven leukemogenesis.?Nature Communications?2019;10(1):4925.

28. Yuan-Liang Zhang, Jie-Wen Sun, Yin-Yin Xie, Yan Zhou, Ping Liu, Jia-Chun Song, Chun-Hui Xu,?Lan Wang, Dan Liu, Ai-Ning Xu, Zhu Chen, Sai-Juan Chen, Xiao-Jian Sun*, Qiu-Hua Huang*. Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation.?Cell Research?2018;28(4):476-490.

29. Na Man, Yu-Rong Tan, Xiao-Jian Sun, Fan Liu, Guo-Yan Cheng, Sarah Greenblatt, Camilo Martinez, Daniel L. Karl, Koji Ando, Ming Sun, Dan Hou, Bing-Yi Chen, Ming-Jiang Xu, Feng-Chun Yang, Zhu Chen, Sai-Juan Chen, Stephen D. Nimer*,?Lan Wang*. Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1 dependent manner.?Blood?2017;129(20):2782-2792.

30. G Cheng, F Liu, T Asai, F Lai, N Man, H Xu, S Chen, S Greenblatt, P-J Hamard, K Ando, X Chen,?Lan Wang, C Martinez, M Tadi,?L Wang, M Xu, F-C Yang, R Shiekhattar, S D Nimer. Loss of p300 accelerates MDS-associated leukemogenesis.?Leukemia?2017;31(6):1382-1390.

31. Jian-Ping Li, Fu-Hong He, Peng Zhang, Shi Chen, Hui Shi, Yan-Ling Sun, Ying Guo, Hui Yang, Na Man, Sarah Greenblatt, Zhaomin Li, Zhengyu Guo, Yuan Zhou,?Lan Wang, Lluis Morey, Sion Williams, Xi Chen, Qun-Tian Wang, Stephen D. Nimer, Peng Yu, Qian-Fei Wang*, Ming-Jiang Xu*, Feng-Chun Yang*. Loss of Asxl2 leads to myeloid malignancies in mice.?Nature Communications?2017;8:15456.

32. Yun-Chi Tang*, Hui Yuwen, Kai-Ying Wang, Peter M. Bruno, Kevin Bullock, Amy Deik, Stefano Santaguida, Marianna Trakala, Sarah J. Pfau, Na Zhong, Tao Huang,?Lan Wang, Clary B. Clish, Michael T. Hemann, Angelika Amon*. Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis.?Cancer Research?2017;77(19):5272-5286.

33. Na Man, Xiao-Jian Sun, Yurong Tan, Marta Garc′?a-Cao, Fan Liu, Guo-Yan Cheng, Megan Hatlen, Haiming Xu, Ronit Shah, Nolan Chastain, Na Liu, Gang Huang, Yuan Zhou, Mengyao Sheng, Jun-Hong Song, Feng-Chun Yang, Robert Benezra, Stephen D. Nimer*,?Lan Wang*. Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin.?Blood?2016;127(19):2322-2326.

34. Fan Liu,?Lan Wang, Fabiana Perna, Stephen D. Nimer*. Beyond transcription factors: how oncogenic signaling reshapes the epigenetic landscape.?Nature Reviews Cancer?2016;16(6):359-372.

35. Kotaro Shirakawa,?Lan Wang, Na Man, Jasna Maksimoska, Alexander W. Sorum, Hyung W. Lim, Intelly S. Lee, Tadahiro Shimazu, John C. Newman, Sebastian Schr?der, Melanie Ott, Ronen Marmorstein, Jordan Meier, Stephen D. Nimer, Eric Verdin*. Salycylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.?Elife?2016;5:e11156.

36. Megan A. Hatlen, Kanika Arora, Vladimir Vacic, Ewa A. Grabowska, Willey Liao, Bridget Riley-Gillis, Dayna M. Oschwald,?Lan Wang, Jacob E. Joergens, Alan H. Shih, Franck Rapaport, Sheng-Qing Gu, Francesca Voza, Takashi Asai, Benjamin G. Neel, Michael G. Kharas, Mithat Gonen, Ross L. Levine, Stephen D. Nimer*. Integrative analysis of the mutational landscape of mouse and human AML identifies functionally relevant leukemia disease alleles.?J Exp Med?2016;213(1):25-34.

37. Lan Wang, Pierre-Jacques Hamard, Stephen D Nimer*. PARP inhibitors: a treatment option for AML??Nature Medicine?2015;21(12):1393-1394.

38. Lan Wang*, Na Man, Xiao-Jian Sun, Yu-Rong Tan, Marta Garcia Cao, Fan Liu, Megan Hatlen, Haiming Xu, Gang Huang, Meredith Mattlin, Arpit Mehta, Evadnie Rampersaud, Robert Benezra, Stephen D. Nimer. Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression.?Blood?2015;126(5):640-650.

39. Fan Liu, Guoyan Cheng, Pierre-Jacques Hamard, Sarah Greenblatt,?Lan Wang, Na Man, Fabiana Perna, Haiming Xu, Madhavi Tadi, Luisa Luciani, Stephen D. Nimer*. Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis.?J Clin Invest?2015;125(9):3532-3544.

40. Xiao-Jian Sun, Na Man, Yurong Tan, Stephen D. Nimer,?Lan Wang*. The role of histone acetyltransferase in normal and malignant hematopoiesis.?Front Oncol?2015; 5:108.

41. Ly P. Vu, Fabiana Perna,?Lan Wang, Francesca Voza, Maria E. Figueroa, Paul Tempst, Hediye Erdjument-Bromage, Rui Gao, Si-Si Chen, Elisabeth Paietta, Tony Deblasio, Ari Melnick, Yan Liu, Xin-Yang Zhao, Stephen D. Nimer*. PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.?Cell Reports?2013;5(6):1625-1638.

42. Xiao-Jian Sun, Zhan-Xin Wang,?Lan Wang, Yanwen Jiang, Nils Kost, T. David Soong, Wei-Yi Chen, Zhan-Yun Tang, Tomoyoshi Nakadai, Olivier Elemento, Wolfgang Fischle, Ari Melnick, Dinshaw J. Patel, Stephen D. Nimer, Robert G. Roeder*. A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis.?Nature?2013;500(7460):93-97.

43. Megan A. Hatlen,?Lan Wang, Stephen D. Nimer*. AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.?Front Med?2012;6(3):248-262.

44. Gang Huang*, Xing-Hui Zhao,?Lan Wang, Shannon Elf, Hao Xu, Xinyang Zhao, Goro Sashida, Yue Zhang, Yan Liu, Jennifer Lee, Silvia Menendez, Youyang Yang, Xiaomei Yan, Pu Zhang, Daniel G. Tenen, Motomi Osato, James J.-D. Hsieh, Stephen D. Nimer*. The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.?Blood?2011;118(25):6544-6552.

45. Lan Wang, Alexander Gural, Xiao-Jian Sun, Xin-Yang Zhao, Fabiana Perna, Gang Huang, Megan A. Hatlen, Ly Vu, Fan Liu, Hai-Ming Xu, Takashi Asai, Hao Xu, Tony Deblasio, Silvia Menendez, Francesca Voza, Yan-Wen Jiang, Philip A. Cole, Jin-Song Zhang, Ari Melnick, Robert G. Roeder, Stephen D. Nimer*. The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.?Science?2011;333(6043):765-769.

46. Fan Liu, Xin-Yang Zhao, Fabiana Perna,?Lan Wang, Priya Koppikar, Omar Abdel-Wahab, Michael W. Harr, Ross L. Levine, Hao Xu, Ayalew Tefferi, Anthony Deblasio, Megan Hatlen, Silvia Menendez, Stephen D. Nimer*. JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation.?Cancer Cell?2011;19(2):283-294.

47. Fabiana Perna, Nadia Gurvich, Ruben Hoya-Arias, Omar Abdel-Wahab, Ross L. Levine, Takashi Asai, Francesca Voza, Silvia Menendez,?Lan Wang, Fan Liu, Xin-Yang Zhao, Stephen D. Nimer*. Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera.?Blood?2010;116(15):2812-2821.

48. Yi-Wen Zhang, Xiao-Xing Jiang, Qiu-Sheng Chena, Wen-Yu Shia,?Lan Wang, Han-Dong Sun, Zhi-Xiang Shen, Zhu Chen, Sai-Juan Chen, Wei-Li Zhao*. Eriocalyxin B induces apoptosis in lymphoma cells through multiple cellular signaling pathways.?Experimental Hematology?2010;38(3):191-201.

49. Lan Wang, Gang Huang, Xinyang Zhao, Megan A. Hatlen, Ly Vu, Fan Liu, Stephen D. Nimer*. Post-translational modifications of Runx1 regulate its activity in the cell.?Blood Cells Mol Dis?2009;43(1):30-34.

50.?Lan Wang, Guang-Biao Zhou, Ping Liu, Jun-Hong Song, Yang Liang, Xiao-Jing Yan, Fang Xu, Bing-Shun Wang, Jian-Hua Ma, Zhi-Xiang Shen, Sai-Juan Chen*, Zhu Chen*. Dissection of mechanism of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia.?Proc Natl Acad Sci U S A?2008;105(12):4826-4831.

51. Wei-Li Zhao#,?Lan Wang#, Yuan-Hua Liu#, Jin-Song Yan#, Christophe Leboeuf, Yan-Yan Liu, Wei-Li Wu, Anne Janinc, Zhu Chen, Sai-Juan Chen*. Combined effects of histone deacetylase inhibitor and rituximab on non-Hodgkin’s B-lymphoma cells apoptosis.?Experimental Hematology?2007;35(12):1801-1811.

52. Guang-Biao Zhou#, Hui Kang#,?Lan Wang#, Li Gao, Ping Liu, Jun Xie, Feng-Xiang Zhang, Xiang-Qin Weng, Zhi-Xiang Shen, Jue Chen, Long-Jun Gu, Ming Yan, Dong-Er Zhang, Sai-Juan Chen, Zhen-Yi Wang, Zhu Chen*. Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.?Blood?2007;109(8):3441-3450.

53.?Lan Wang, W-L Zhao, J-S Yan, P Liu, H-P Sun, G-B Zhou, Z-Y Weng, W-L Wu, X-Q Weng, X-J Sun, Z Chen*, H-D Sun*, S-J Chen*. Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner.?Cell Death and Differentiation?2007;14(2):306-317.

54.?Lan Wang, Sai-Juan Chen. Monoclonal antibodies treat hematopoietic malignancies.?Shanghai: Shanghai Science and Technology Press?2006;pp.309-322.

55.?Xiao-Jian Sun, Ju Wei, Xin-Yan Wu, Ming Hu,?Lan Wang, Hai-Hong Wang, Qing-Hua Zhang, Sai-Juan Chen, Qiu-Hua Huang*, Zhu Chen*. Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase.?J Biol Chem?2005;280(42):35261-35271.